Maintaining a healthy gut microbiome is essential for overall well-being. One of the easiest ways to support a healthy and diverse gut microbiome is to eat a variety of prebiotics and probiotics. While they sound similar, they serve distinct functions in supporting our digestive and immune systems. Understanding the difference between the two and how to incorporate them into your diet can have really impactful effects on your health.
Probiotics are live beneficial bacteria that naturally reside in our gut. They help maintain a balanced microbiome, aid digestion, and bolster the immune system. By replenishing beneficial bacteria in the intestines, probiotics can help protect against harmful pathogens and support various bodily functions, including metabolism, mental health, and immune response.
Prebiotics are fibers and compounds like beta-glucans and resistant starch that humans can’t digest (but our gut microbes love them!). They are essentially food for our good gut bacteria. By nourishing these bacteria, prebiotics help support a healthy microbiome by promoting the growth of good bacteria while keeping harmful bacteria in check. Unlike probiotics, which are live organisms, prebiotics are found in certain fiber-rich foods and are essential for sustaining the gut flora.
A harmonious relationship between prebiotics and probiotics is essential for optimal health. Probiotics introduce beneficial bacteria into the gut, while prebiotics act as their fuel, allowing them to thrive and maintain balance. When these two work together, they:
Jenkins, G., & Mason, P. (2022). The role of prebiotics and probiotics in human health: A systematic review with a focus on gut and immune health. Food & Nutrition Journal, 7, 245. https://www.hsis.org/wp-content/uploads/2022/08/Food-Nutrition-Journal-The-Role-of-Prebiotics-and-Probiotics-in-Human-Health-A-Systematic-Review-with-a-Focus-on-Gut-and-Immune-Health.pdf
Micenková, L., Brodíková, K., Smetanová, S., Bosák, J., Šmajs, D., Andrla, P., & Budinská, E. (2024). High colonization by probiotic Escherichia coli A0 34/86 strain is associated with a less diverse microbiome related to children’s age. Beneficial Microbes, 15(1). https://www.wageningenacademic.com/doi/10.3920/BM2023.0101
Larsen, O. F. A., Claassen, E., & Brummer, R. J. (2020). On the importance of intraindividual variation in nutritional research. Beneficial Microbes, 11(4), 327–332. https://www.wageningenacademic.com/doi/10.3920/BM2020.0014
Hepburn, N. J., Garaiova, I., Williams, E. A., Michael, D. R., & Plummer, S. (2013). Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: A preliminary study using healthy individuals. Beneficial Microbes, 4(4), 303–307. https://www.wageningenacademic.com/doi/10.3920/BM2013.0020
Micenková, L., Brodíková, K., Smetanová, S., Bosák, J., Šmajs, D., Andrla, P., & Budinská, E. (2024). High colonisation by probiotic Escherichia coli A0 34/86 strain is associated with a less diverse microbiome related to children’s age. Beneficial Microbes, 15(1). https://www.wageningenacademic.com/doi/10.3920/BM2023.0101
Hepburn, N. J., Garaiova, I., Williams, E. A., Michael, D. R., & Plummer, S. (2013). Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: A preliminary study using healthy individuals. Beneficial Microbes, 4(4), 303–307. https://www.wageningenacademic.com/doi/10.3920/BM2013.0020
Larsen, O. F. A., Claassen, E., & Brummer, R. J. (2020). On the importance of intraindividual variation in nutritional research. Beneficial Microbes, 11(4), 327–332. https://www.wageningenacademic.com/doi/10.3920/BM2020.0014
Jenkins, G., & Mason, P. (2022). The role of prebiotics and probiotics in human health: A systematic review with a focus on gut and immune health. Food & Nutrition Journal, 7, 245. https://www.hsis.org/wp-content/uploads/2022/08/Food-Nutrition-Journal-The-Role-of-Prebiotics-and-Probiotics-in-Human-Health-A-Systematic-Review-with-a-Focus-on-Gut-and-Immune-Health.pdf
Micenková, L., Brodíková, K., Smetanová, S., Bosák, J., Šmajs, D., Andrla, P., & Budinská, E. (2024). High colonisation by probiotic Escherichia coli A0 34/86 strain is associated with a less diverse microbiome related to children’s age. Beneficial Microbes, 15(1). https://www.wageningenacademic.com/doi/10.3920/BM2023.0101
Hepburn, N. J., Garaiova, I., Williams, E. A., Michael, D. R., & Plummer, S. (2013). Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: A preliminary study using healthy individuals. Beneficial Microbes, 4(4), 303–307. https://www.wageningenacademic.com/doi/10.3920/BM2013.0020
Larsen, O. F. A., Claassen, E., & Brummer, R. J. (2020). On the importance of intraindividual variation in nutritional research. Beneficial Microbes, 11(4), 327–332. https://www.wageningenacademic.com/doi/10.3920/BM2020.0014
Jenkins, G., & Mason, P. (2022). The role of prebiotics and probiotics in human health: A systematic review with a focus on gut and immune health. Food & Nutrition Journal, 7, 245. https://www.hsis.org/wp-content/uploads/2022/08/Food-Nutrition-Journal-The-Role-of-Prebiotics-and-Probiotics-in-Human-Health-A-Systematic-Review-with-a-Focus-on-Gut-and-Immune-Health.pdf
Micenková, L., Brodíková, K., Smetanová, S., Bosák, J., Šmajs, D., Andrla, P., & Budinská, E. (2024). High colonisation by probiotic Escherichia coli A0 34/86 strain is associated with a less diverse microbiome related to children’s age. Beneficial Microbes, 15(1). https://www.wageningenacademic.com/doi/10.3920/BM2023.0101
Hepburn, N. J., Garaiova, I., Williams, E. A., Michael, D. R., & Plummer, S. (2013). Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: A preliminary study using healthy individuals. Beneficial Microbes, 4(4), 303–307. https://www.wageningenacademic.com/doi/10.3920/BM2013.0020
Larsen, O. F. A., Claassen, E., & Brummer, R. J. (2020). On the importance of intraindividual variation in nutritional research. Beneficial Microbes, 11(4), 327–332. https://www.wageningenacademic.com/doi/10.3920/BM2020.0014
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Morgan Goodstadt, MS, RD, CDN, LDN, IFNCP
Registered Dietitian, Master’s in Clinical Nutrition, Certified Integrative and Functional Nutritionist and Health Coach. Morgan combines her expertise in nutrition with evidenced-based functional medicine and experience in human behavior to help her clients improve their health, relationship with food, and overall wellbeing. Her philosophy aims to achieve balance in both the diet and other areas of life.
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